Growth Control: p53, the Guardian Angel of Compensatory Proliferation
نویسنده
چکیده
Compensatory growth, or regeneration, is used to replace damaged tissue during animal development. Recent work has revealed a new role for Drosophila p53 in the compensatory proliferation of cells that are needed to repair damaged tissues, a role that requires the non-apoptotic function of the caspase protease Dronc.
منابع مشابه
Compensatory Proliferation in Drosophila Imaginal Discs Requires Dronc-Dependent p53 Activity
BACKGROUND The p53 transcription factor directs a transcriptional program that determines whether a cell lives or dies after DNA damage. Animal survival after extensive cellular damage often requires that lost tissue be replaced through compensatory growth or regeneration. In Drosophila, damaged imaginal disc cells can induce the proliferation of neighboring viable cells, but how this is contro...
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عنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006